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The Los Angeles Lakers will face off against the Philadelphia 76ers in an interconference matchup on Friday. Los Angeles is 37-32 overall and 25-12 at home, while Philadelphia is 37-31 overall and 17-16 on the road. The 76ers have won seven straight games against the Lakers, including winning 138-94 in Philadelphia on Nov. 27.

Tipoff is set for 10:30 p.m. ET at Crypto.com Arena in Los Angeles. The Lakers are 7.5-point favorites in the latest 76ers vs. Lakers odds, according to the SportsLine consensus, and the over/under is 224.5 points. Before entering any Lakers vs. 76ers picks, you need to see the NBA predictions and betting advice from SportsLine's advanced computer model

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five-plus seasons. The model enters Week 22 of the 2023-24 NBA season on a sizzling 74-48 roll on all top-rated NBA picks this season, returning nearly $2,400. Anyone following it has seen huge returns.

The model has set its sights on Los Angeles vs. Philadelphia. You can head to SportsLine to see its picks. Here are several NBA odds and betting lines for Sixers vs. Lakers:

  • Lakers vs. 76ers spread: Lakers -7.5
  • Lakers vs. 76ers over/under: 224.5 points
  • Lakers vs. 76ers money line: Lakers: -305, 76ers: +243
  • PHI: The 76ers are 2-1 ATS over their last three games
  • LAL: The Lakers are 3-1 ATS over their last four games
  • Lakers vs. 76ers picks: See picks at SportsLine

What to know about the 76ers

The 76ers are coming off a 115-102 loss to the Suns on Wednesday, snapping a two-game winning streak. Philadelphia is 3-6 over its last nine contests, including 1-4 on the road during that span. Tyrese Maxey had a poor showing with six points on 3 of 13 shooting against the Suns, but he was coming off three straight 30-point performances. Kelly Oubre Jr. has played a key role this month, averaging 20.4 points and 6.1 rebounds over 10 games in March.

The Sixers have needed a stout defensive effort to remain competitive with Joel Embiid (knee) out a significant portion of the season, and they've gotten that on most nights. Philadelphia is ninth in scoring defense (112.4 points per game) while ranking ninth in opponent's effective field goal percentage. The Sixers have held their opponents to below 110 points in five of their last six games. Tobias Harris (ankle) is questionable and has missed three straight games, while De'Anthony Melton (back) remains out. See which team to pick here.

What to know about the Lakers

The Lakers are coming off a 136-105 win over the Hawks at home on Monday as Los Angeles continues its long stretch of games played in California. After Friday against the 76ers, nine of their last 10 games will have been played at home with 11 straight games being played in California. The Lakers are 5-3 over their last eight home games and 6-4 during their current California stretch, including 5-5 ATS over that span.

LeBron James (ankle) is questionable and Anthony Davis (Achilles) is probable as they've been the majority of the season. Both played on Monday and given their long stretch of days off, it's likely both will be in the lineup on Friday. James is averaging 25.5 points, 7.2 rebounds and 8.1 assists and is eighth in the NBA in scoring in his 21st NBA season. Davis is adding 24.4 points and 12.3 rebounds this year. D'Angelo Russell has taken over a key role, especially over the last month, averaging 20.8 points and 6.6 assists over eight games in March. See which team to pick here.

How to make Lakers vs. 76ers picks

The model has simulated 76ers vs. Lakers 10,000 times and the results are in. We can tell you that the model is leaning Over and it also says one side of the spread hits over 60% of the time. You can only see the pick at SportsLine.

So who wins Lakers vs. Sixers, and which side of the spread hits over 60% of the time? Visit SportsLine now to see which side of the Sixers vs. Lakers spread you need to jump on Friday, all from the model on a 74-48 roll on all top-rated NBA picks this season, and find out. 

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